Treatment for Hypoactive Sexual Desire
نویسنده
چکیده
Flibanserin acts at cortical, limbic, hypothalamic, and brainstem nuclei to inhibit serotonin release by binding to 5-HT1A autoreceptors and block postsynaptic action of serotonin at 5-HT2A receptors. This gradually disinhibits the turnover of other monoamines like dopamine and noradrenaline that are critical for sexual desire.
منابع مشابه
Brain-Behavioral Systems and Psychological Distress in Women with Hypoactive Sexual Desire Disorder
Background: Hypoactive sexual desire disorder is the most common sexual disorder among women, which interferes with their various functions. Activity of brain-behavioral and psychological distress systems are considered among factors affecting sexual function. Objectives: The present study aimed to compare women with hypoactive sexual desire and normal women in terms of brain-behavioral and ...
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ISSUE Hypoactive sexual desire disorder (HSDD) is hypothesized to be a disorder of the brain's reward circuitry. Neurotransmitters in reward circuits are thus therapeutic targets for improving sexual desire. Novel treatment strategies are to enhance dopamine (DA) actions, reduce serotonin (5-HT) actions, or both.
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With advancing age, there is an increase in the complaints of a lack of a libido in women and erectile dysfunction in men. The efficacy of phosphodiesterase type 5 inhibitors, together with their minimal side effects and ease of administration, revolutionized the treatment of erectile dysfunction. For women, testosterone administration is the principal treatment for hypoactive sexual desire dis...
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ورودعنوان ژورنال:
- Cell
دوره 163 شماره
صفحات -
تاریخ انتشار 2015